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KMID : 0383819790260010024
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Tuberculosis and Respiratory Diseases
1979 Volume.26 No. 1 p.24 ~ p.26
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The Effect of Ethambutol on Uric Acid Metabolism
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민우성/Wu Sung Min
조의숙/백남종/정진우/박성학/변해원/Eui Suk Cho/Nam Jong Back/Jin Wu Jeong/Sung Hak Park/Hae Won Byun
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Abstract
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Ethambutol has found its wide clinical acceptance as an effective agents for the
treatment of My cobacterium Tuberculosis infection in human. There were different
reports that ethambutol has an effect on the uric acid metabolism by some authors. We
studied the effect of ethambutol therapy in a daily dose of 890㎎ on the uric acid
metabolism in 40 active tuberculosis patients (male : 14 and female 26), who had normal
kidney function and no metabolic disorders, on a regular hospital low-purine diet.
1) The storm concentration of uric acid were 3.2±0.9㎎/dl before treatment and 4.1±1.3
㎎/dl after ethambutol therapy for 5 days.
2) The ratio of urate clearance to creatinine clearance (C urate/C creatinine) were 0.16
±0.09 before treatment and 0.15±0.08 after ethambutol therapy for 5 days.
3) The ratio of urine urate to urine creatinine ( U urate/U creatinine) were 0.60±0.18
before treatment and 0.54±0.20 after ethambutol therapy for 5 days.
Our studies suggests that ethambutol produces hyperuricemia by decreasing renal
clearance of uric acid.
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KEYWORD
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